Kary Mullis won the Nobel Prize for the invention of PCR in 1983 building on other prizes in 1957, 1968 and 1977. It remains the gold standard for interrogating RNA and DNA to this day. No Nobel Prize has been awarded to molecular diagnostics in the four decades since.
Clever, intricate but iterative improvements on PCR (Hot Start Taq, qPCR, dPCR, LAMP, SDA, RPA, NEAR, HDA) trade for billions of dollars but no paradigm shift in molecular diagnostics has arisen.
Detection by Proxy differs in that RNAs of interest are transduced into coded nanoparticles and these are read by a semiconductor sensor.
The RNA is purified in the process but is not modified or copied in any way. Detection by Proxy thus also works as sample prep for all other molecular techniques.
The recent pandemic is estimated to cost $5.6 trillion. A contributory factor was the reliance on centralised PCR testing. The logistics surrounding this model are very slow and remove control of the process from individuals. It is unsuitable for real time monitoring and places unacceptable burdens on the population.